83976-52-7

Upstream product

• 86661-23-6 dimethyl 2‐{(S)‐phenyl[(1S)‐2‐oxocyclohexyl]methyl}propanedioate 
• 86661-28-1 (-)-(βR,2S)-β-Phenylspirodithiolan>-2-propansaeure-methylester 
• 86661-27-0 (-)-(3R,1'S)-3-(2-Oxocyclohexyl)-3-phenylpropansaeure-methylester 
• 86661-29-2 (-)-(βR,2S)-β-Phenylspirodithiolan>-2-propionamid 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 84025-88-7 (+)-(2R,3S,6'S,1''R)-3-Methyl-N-<6'-(2''-nitro-1''-phenylaethyl)-1-cyclohexenyl>-2-phenylmorpholin 
• 83976-43-6 (2R,3S)-N-(1'-Cyclohexenyl)-3-methyl-2-phenylmorpholin 
• 4591-64-4 (S)-2-[(R)-2-nitro-1-phenylethyl]cyclohexanone 
• 108-94-1 cyclohexanone 
• 5153-67-3 nitrostyrene 
• 83976-51-6 (+)-(2S,1'R)-2-(2'-Nitro-1'-phenylaethyl)-cyclohexanon-aethylendithioacetal 
• 86661-30-5 (+)-(βR,2S)-β-Phenylspirodithiolan>-2-ethanamin 

Downstream Products

• 83976-53-8 (+)-(2R)-N-(2-Cyclohexyl-2-phenylaethyl)-methansulfonsaeureamid 

Relevant academic research and scientific papers

Asymmetric Michael Additions. Stereoselective Alkylations of the (R)- and (S)-Enamine from Cyclohexanone and 2-(Methoxymethyl)pyrrolidine by Methyl α-(Methoxycarbonyl)cinnamates

Alkylation of (2S)-1-(1-cyclohexen-1-yl)-2-(methoxymethyl)pyrrolidine ((S)-1, enamine from cyclohexanone and 2-(methoxymethyl)pyrrolidine) by the Knoevenagel condensation products 4 of aromatic aldehydes yields 35-76percent of Michael adducts (1 + 4 -> ->

Asymmetrische Michael-Additionen. Praktisch vollstaendig diastereo- und enantioselective Alkylierungen des Enamins aus Cyclohexanon und Prolinylmethylaether durch ω-Nitrostyrole zu u-2-(1'-Aryl-2'-nitroaethyl)cyclohexanonen

When the enamine (S)-N-(1'-cyclohexenyl)-2-methoxymethyl-pyrrolidine is added to 2-aryl-1-nitroethylenes, only one of the four possible enantiomerically pure diastereomers is formed.Hydrolysis of the crude primary products furnishes α-alkylated cyclohexanones of >90percent e.e. (3, Scheme 3).Their (2S,1'R)-configuration was deduced by chemical correlation with 1-cyclohexyl-1-phenyl-ethane and from an X-ray crystal structure analysis of (-)-(2R,3S,6'R,1''S)-3-methyl-N--2-phenylmorpholine (11a, Scheme 5 and Fig. 2). - The relative topicity of reactant approach with the prolinol derivative (see II) is specified as 1k,ul-1,4.The steric course and the mechanism of the reaction are discussed.