84-02-6 Usage
Uses
Used in Pharmaceutical Industry:
Prochlorperazine maleate is used as an antipsychotic agent for its high potency and effectiveness in treating various mental health conditions.
Used in Oncology:
Prochlorperazine maleate is used to increase tumor cell antigen presentation, enhancing the efficacy of anti-tumor monoclonal antibodies (mAbs) in cancer treatment.
Used in Migraine Treatment:
Prochlorperazine maleate is used as an antimigraine agent, helping to alleviate the symptoms and frequency of migraine headaches.
Used in Antiemetic Therapy:
Prochlorperazine maleate is used as an antiemetic agent, primarily due to its high potency and effectiveness in preventing and treating nausea and vomiting.
Biological Activity
D 2 receptor antagonist. Also interacts with 5-HT 3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo .
Biochem/physiol Actions
Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic
References
References/Citations
1) Daniel?et al.?(2015),?Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic,?16?635
2) Chew?et al.?(2020),?Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell,?180?895
3) Hollister?et al.?(1969),?Clinical use of psychotherapeutic drugs: current status;?Clin. Pharmacol. Ther.,?10?170
4) Cook and Newberry (2018),?Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J.,?40?148
5) Van den Berg?et al.?(1996),?The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care,?24?538
Check Digit Verification of cas no
The CAS Registry Mumber 84-02-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 84-02:
(4*8)+(3*4)+(2*0)+(1*2)=46
46 % 10 = 6
So 84-02-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)
