84-04-8 Usage
Originator
Mornidine ,Searle ,US ,1959
Uses
Pipamazine is a drug od the phenothiazine class which used to be used as an antiemetic.
Manufacturing Process
To a stirred and refluxing suspension of 4.95 parts of 4piperidinecarboxamide, 1 part of sodium iodide and 8.4 parts of potassium carbonate in 40 parts of butanone there are added in the course of 30 minutes 9.3 parts of 2-chloro-10-(γ-chloropropyl)phenothiazine in 40 parts ofbutanone. Stirring and refluxing are continued for 12 hours after which the mixture is cooled and filtered. The filtrate is concentrated under vacuum to give a residue which is recrystallized from a mixture of 2-propanol and petroleum ether. The 1-[γ-(2'-chloro-10'-phenothiazine)propyl]piperidine-4carboxamide thus obtained melts at approximately 139°C.This base is dissolved in a small amount of 2-propanol and treated with a 25% solution of hydrogen chloride in 2-propanol. Upon treatment of this solution with anhydrous ether a hydrochloride precipitates as a white solid melting at about 196°C to 197°C with formation of bubbles.
Brand name
Normetine;.
World Health Organization (WHO)
Pipamazine, which is pharmacologically similar to
chlorpromazine, was introduced in 1959 for the treatment of nausea and vomiting.
Although it was withdrawn in 1969 by the United States FDA on grounds of lack of
proof of efficacy and safety, it remains available in some countries.
Check Digit Verification of cas no
The CAS Registry Mumber 84-04-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 84-04:
(4*8)+(3*4)+(2*0)+(1*4)=48
48 % 10 = 8
So 84-04-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H24ClN3OS/c22-16-6-7-20-18(14-16)25(17-4-1-2-5-19(17)27-20)11-3-10-24-12-8-15(9-13-24)21(23)26/h1-2,4-7,14-15H,3,8-13H2,(H2,23,26)
