84003-57-6

Upstream product

• 1589-82-8 phenylmagnesium bromide 
• 150721-86-1 9-benzyl-2-chloro-6-iodopurine 
• 1262613-52-4 C₁₂H₁₁ClN₆ 
• 79064-26-9 9-benzyl-2,6-dichloro-9H-purine 

Downstream Products

• 1106770-06-2 9-benzyl-N,N-dimethyl-9Hpurin-2-amine 
• 1107661-50-6 9-benzyl-N-methyl-9Hpurin-2-amine 

Relevant academic research and scientific papers

The synthesis of nebularine and its analogs via oxidative desulfuration in aqueous nitric acid

The synthesis of nebularine and its analogs has been achieved via oxidative desulfuration in H2O for the first time. With 50% HNO3as an oxidant and solvent, 18 products were obtained in good yields (70%–94%). The oxidative desulfuration system could tolerate different functional groups including fluoro, chloro, amino, alkyl, allyl, ribosyl, deoxyribosyl, and arabinofuranosyl groups.More importantly, the drug nebularine could be obtained successfully on a 20 g scale, which made this route more attractive for industrial applications.

Efficient synthesis of nebularine and vidarabine via dehydrazination of (hetero)aromatics catalyzed by CuSO4 in water

A simple dehydrazination reaction has been achieved in the presence of a catalytic amount of CuSO4 for the first time. With CuSO4 (2 mol%) as a catalyst and water as a solvent, the dehydrazination products were obtained in good yields (66-95%). Moreover, the drugs nebularine and vidarabine were afforded successfully, and vidarabine could be produced on a 0.923 kg scale, which shows good potential for industrial applications.

Selective magnesiation of chloro-iodopurines: An efficient approach to new purine derivatives

Both 6-chloro-2-iodo-9-isopropylpurine (1) and 2-chloro-6-iodo-9- benzylpurine (4) undergo a selective I/Mg exchange reaction with iPrMgCl at -80 °C. The reaction course at 0 °C is different. Magnesiation of 1 proceeds with the migration of magnesium to t