84016-49-9Relevant academic research and scientific papers
Method of preparing α-aromatic propionic acids and intermediates thereof
-
, (2008/06/13)
A method for the preparation of an ester of α-thio-α-aromatic propionic acid derivatives of the formula: STR1 wherein R1 is alkyl, phenyl or benzothiazolyl, R2 is alkyl and Ar is an aromatic substituent. The method comprises reacting an ester of α-chloro-α-thiopropionic acid of the formula: STR2 with an aromatic compound of the formula ARH, in the presence of a Lewis acid. The method provides good reactivity and positional selectivity in the Friedel-Crafts reaction. Many esters of the formula (2) are useful as pharmaceuticals, agricultural chemicals, perfumes or their intermediates.
