84040-68-6

Upstream product

• 186581-53-3 diazomethane 
• 72313-44-1 4-{3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl} benzoic acid 
• 72313-43-0 ethyl 4-{3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoate 
• 72313-38-3 ethyl 4-<3-<2-(1,3-dioxolanyl)>propyl>benzoate 
• 72313-37-2 ethyl 4-(3-formylpropyl)benzoate 
• 99-94-5 p-Toluic acid 
• 108-94-1 cyclohexanone 
• 39884-50-9 1-(2-aminoethyl)cyclohexanol 
• 14368-55-9 2-(1-hydroxycyclohexyl)acetonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 84040-56-2 (+)-4-(3-{3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl}propyl)benzoic acid 
• 84040-57-3 (-)-4-(3-{3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl}propyl)benzoic acid 
• 84064-04-0 (-)-methyl 4-<3-<3-<2-<1-<(1S)-ω-camphanyloxy>cyclohexyl>ethyl>-4-oxo-2-thiazolidinyl>propyl>benzoate 
• 84040-69-7 (+)-methyl 4-<3-<3-<2-<1-<(1S)-ω-camphanyloxy>cyclohexyl>ethyl>-4-oxo-2-thiazolidinyl>propyl>benzoate 

Relevant academic research and scientific papers

ANTIHYPERTENSIVE COMPOSITION

A pharmaceutical composition is disclosed which comprises the combination of interphenylene 9-thia-11-oxo-12-aza prostanoic acid derivatives and carboxyalkyl dipeptide derivatives.

Anti-inflammatory composition

A pharmaceutical composition containing an interphenylene 9-thia-11-oxo-12-aza prostanoic acid type renal vasodilator and a non-steroidal anti-inflammatory agent and its use are disclosed.

Intermediates for the resolution of some interphenylene-9-thia-11-oxo-12-azaprostanoic acids

Some derivatives of interphenylene-9-thia-11-oxo-12-azaprostanoic acid which are active renal vasodilator agents are resolved via diastereomeric camphanyl or camphorcarbonyl esters. Upon hydrolysis, the separated diastereoisomers yield optically pure enan

Interphenylene 9-thia-11-oxo-12-aza-prostanoic acids

This invention relates to novel interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof. These compounds are exceptionally potent renal vasodilators and antihypertensives which are active when administered orally but which have a more specific type of biological activity than that of many of the natural prostaglandins and their synthetic analogs or derivatives.