84050-30-6Relevant academic research and scientific papers
(Imidazolylphenyl)pyrrol-2-one inhibitors of cardiac cAMP phosphodiesterase
Lampe,Chou,Hanna,Di Meo,Erhardt,Hagedorn III,Ingebretsen,Cantor
, p. 1041 - 1047 (2007/10/02)
Seven 3-alkyl-4-aryl-1,5-dihydro-2H-pyrrol-2-ones were prepared as potential inhibitors of cardiac cAMP phosphodiesterase (PDE). The design of these compounds made use of rolipram, a known inhibitor of the brain cAMP PDE isozyme, as a lead structure and w
Pyrimidine Derivatives. 4. Synthesis and Antihypertensive Activity of 4-Amino-2-(4-cinnamoylpiperazino)-6,7-dimethoxyquinazoline Derivatives
Sekiya, Tetsuo,Hiranuma, Hidetoshi,Hata, Shunsuke,Mizogami, Susumu,Hanazuka, Mitsuo,Yamada, Shun-ichi
, p. 411 - 416 (2007/10/02)
A series of 30 4-amino-2-(4-cinnamoylpiperazino)-6,7-dimethoxyquinazoline derivatives was prepared and tested for their ability to reduce blood pressure in conscious, spontaneously hypertensive rats (SHR).A number of these compounds, notably 4-amino-2-(4-
