840503-08-4Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of novel benzoylazole-based PPAR α/γ activators
Ushiroda, Kantaro,Maruta, Katsunori,Takazawa, Takeshi,Nagano, Tomokazu,Taiji, Mutsuo,Kohno, Tetsuya,Sato, Yasuhiro,Horai, Shinji,Yanagi, Kazunori,Nagata, Ryu
scheme or table, p. 1978 - 1982 (2011/04/24)
In our search for new PPARα/γ agonists, we designed and synthesized a series of benzoylazole-based carboxylic acids. Compound 9 showed potent PPARγ partial agonistic activity with modest PPARα agonistic activity. The sodium salt of 9 (9Na) demonstrated po
NOVEL HETEROARYL DERIVATIVE
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Page/Page column 42, (2008/06/13)
A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally substituted lower alkylene, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, W3 is a single bond, a lower alkylene, a lower alkenylene, etc., W4 is a single bond, -NR10-, etc., Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.
