84078-19-3

Upstream product

• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 
• 14398-34-6 4-(3-hydroxy-2,6,6-trimethylcyclohex-1-enyl)but-3-en-2-one 
• 37384-77-3 ethyl β-ionylidene acetate 

Downstream Products

• 49816-98-0 ethyl (4E)-3-methyl-5-(3-oxo-2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienoate 
• 49817-06-3 ethyl (4E)-3-methyl-5-(3-oxo-2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienoate 
• 127891-29-6 (E)-5-[5-Hydroxy-2,2-dimethyl-6-methylene-cyclohex-(Z)-ylidene]-3-methyl-pent-3-enoic acid ethyl ester 
• 84078-20-6 (-)-(3'R,2E,4E)-5-<3'-Trimethylsilyloxy-2',6',6'-trimethyl-1'-cyclohexenyl>-3-methyl-2,4-pentadiensaeure-aethylester 
• 84078-24-0 (-)-(3'R,2E,4E)-5-<3'-Trimethylsilyloxy-2',6',6'-trimethyl-1'-cyclohexenyl>-3-methyl-2,4-pentadienal 
• 84078-23-9 (-)-(3'R,2E,4E)-5-<3'-Trimethylsilyloxy-2',6',6'-trimethyl-1'-cyclohexenyl>-3-methyl-2,4-pentadienol 

Relevant academic research and scientific papers

Access to forskolin precursors via pericyclic reactions

A strategy towards key intermediates in the synthesis of forskolin is presented, which relies on the electrocyclization of the easily accessible triene 5.The mechanism and the selectivity of the reaction under various conditions are discussed.Key words: f

A Simple Access to a Forskolin precursor.

Key intermediates in a forskolin synthesis have been prepared in two steps from hydroxy-β-ionone by electrocyclisation.

Isozeaxanthine: Chiralitaet und enantioselektive Synthese von (4R,4'R)-Isozeaxanthin((-)-(4R,4R')-β,β-Carotin-4,4'-diol)

The absolute configuration of optically active isozeaxanthin was established by synthesis using (-)-(R)-4-hydroxy-β-ionon (2) as starting material.

Retinoic acid analogues with ring modifications. Synthesis and pharmacological activity

Analogues of retinoic acid that have their major modifications in the 5,6 double bond and 4-methylene group regions of the β-cyclogeranylidene ring have been synthesized as potential agents for the treatment and prevention of epithelial cancer. These modi