84080-70-6 Usage
Description
2-Methoxycarbonylmethoxyimino-4-chloro-3-oxobutyric acid, also known as (Z)-4-Chloro-2-((2-methoxy-2-oxoethoxy)imino)-3-oxobutanoic Acid, is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique chemical structure, which includes a chloro substituent, an oxoimino group, and a carboxylic acid moiety.
Uses
Used in Pharmaceutical Industry:
2-Methoxycarbonylmethoxyimino-4-chloro-3-oxobutyric acid is used as an intermediate in the synthesis of Cefixime-13C,15N2 (C242802), a labeled version of Cefixime (C242800). Cefixime is an orally active, third-generation cephalosporin antibiotic that is effective against a wide range of bacterial infections. Its unique structure allows for the incorporation of stable isotopes, which can be used for research and diagnostic purposes, as well as for the development of new pharmaceutical formulations with improved properties.
Check Digit Verification of cas no
The CAS Registry Mumber 84080-70-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,0,8 and 0 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 84080-70:
(7*8)+(6*4)+(5*0)+(4*8)+(3*0)+(2*7)+(1*0)=126
126 % 10 = 6
So 84080-70-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H8ClNO6/c1-14-5(11)3-15-9-6(7(12)13)4(10)2-8/h2-3H2,1H3,(H,12,13)
84080-70-6Relevant articles and documents
Synthesis of (Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids
Lopez, Miguel,Rodriguez, Zalua,Gonzalez, Maritza,Valdes, Barbara,Velez, Herman,Fini, Adamo
, p. 40 - 46 (2007/10/03)
(Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids were synthesized by a new method based on the following sequence of reactions: treatment of the tert-butyl acetoacetate with sodium nitrite, alkylation of the oxime formed with an appropriate alkyl halide, halogenation of methyl α-keto group and simultaneous cleavage of tert-butyl ester with sulfuryl chloride, protection of the obtained acid function with diphenyldiazomethane, formation of the 2-aminothiazole ring by the Hantzsch method with thiourea, formylation of the amino group and selective final cleavage of the diphenylmethyl ester by treatment with trifluoroacetic acid and anisol. The developed procedure allows the synthesis of (Z)-2-(2- formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids, with an ester function in the alkoxyimino group employing a simple method and obtaining higher yields in comparison with the habitually used classic method. (C) 2000 Elsevier Science S.A.