841-12-3Relevant academic research and scientific papers
Synthesis of new phenolic compounds and biological evaluation as antiproliferative agents
Ibrahim, Marwa A,George, Riham F,Abou-Seri, Sahar M,El-Moghazy, Samir M
, p. 181 - 192 (2020/01/06)
New series of phenolic azomethine compounds in addition to 5-arylidene thiazolidinones are synthesized and screened for their anticancer activity against the brain cancer cell line SNB-75 and non-small lung cancer cells HOP-92. The azomethine derivative 12b is the most active compound against SNB-75 displaying an IC50 value of 0.14 μM. Compounds 7b, 16a and 27d display submicromolar activity against the HOP-92 cell line with IC50 values of 0.73, 0.74 and 0.81 μM, respectively. Moreover, studying the cytotoxic effects of the most active compounds against normal lung cells WI-38 revealed that compounds 7b, 16a and 27d showed high safety profiles as anticancer agents.
A photosensitive color-changing material and its color-changing in the dress material application (by machine translation)
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Paragraph 0074; 0077, (2017/08/14)
The present invention provides a novel structure containing Schiff base unit of spiral wicked qinqin kind of type I compounds, the compound is a photosensitive color-changing material of a small organic molecule. The invention also provides a synthetic method of containing the Schiff base unit piperazine compounds. The compounds of this invention can be used as a dye, to aldehyde fabric, is aldehyde fabric can be in the nature change color under the sunlight. (Type I). (by machine translation)
Qualitative analysis of the stability of the oxazine ring of various benzoxazine and pyridooxazine derivatives with proton nuclear magnetic resonance spectroscopy
Moloney,Craik,Iskander
, p. 692 - 697 (2007/10/02)
A series of 3,4-dihydro-1,3-benzoxazine and 3,4-dihydro-1,3-pyridooxazine derivatives was synthesized, and the hydrolysis of the derivatives was studied with proton nuclear magnetic resonance spectroscopy. The oxazine derivatives underwent various degrees of hydrolysis when H2O was added to dimethyl sulfoxide solutions of the compounds. The rates and extents of decomposition of the oxazine ring systems depended on the electronic effects of substituents within the molecules. Examination of the proton nuclear magnetic resonance spectra that were generated during decomposition of the oxazines and trends in stability of the oxazine derivatives suggest the formation of an intermediate in the hydrolysis mechanism.
Transition-state analogues as inhibitors for GABA-aminotransferase
Iskander, MN,Andrews, PR,Winkler, DA,Brinkworth, RI,Paola, C Di,et al.
, p. 129 - 136 (2007/10/02)
Our previous calculations on the reaction catalysed by GABA-aminotransferase (GABA-T) have been utilized in this work in order to synthesize a series of reversible inhibitors of this enzyme.The synthesized transition-state analogues and their precursors i
