841-31-6Relevant academic research and scientific papers
Organocatalytic direct difluoromethylation of aldehydes and ketones with TMSCF2H
Du, Guang-Fen,Wang, Ying,Gu, Cheng-Zhi,Dai, Bin,He, Lin
, p. 35421 - 35424 (2015/05/05)
An organic Lewis base promoted direct difluoromethylation reaction of carbonyl compounds with Me3SiCF2H has been studied. The Schwesinger's superbase can efficiently activate the Si-CF2H bond and initiate the difluoromethy
Efficient and direct nucleophilic difluoromethylation of carbonyl compounds and imines with Me3SiCF2H at ambient or low temperature
Zhao, Yanchuan,Huang, Weizhou,Zheng, Ji,Hu, Jinbo
supporting information; experimental part, p. 5342 - 5345 (2011/12/02)
Since 1995, Me3SiCF2H has been widely believed to be an inefficient difluoromethylating agent, which requires harsh reaction conditions to cleave its rather inert Si-CF2H bond. However, it has now been found that, by using
