84102-43-2Relevant academic research and scientific papers
CCR5 receptor antagonists: Discovery and SAR study of guanylhydrazone derivatives
Wei, Robert G.,Arnaiz, Damian O.,Chou, Yuo-Ling,Davey, Dave,Dunning, Laura,Lee, Wheeseong,Lu, Shou-Fu,Onuffer, James,Ye, Bin,Phillips, Gary
, p. 231 - 234 (2007/10/03)
High throughput screening (HTS) led to the identification of the guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde as a CCR5 receptor antagonist. Initial modifications of the guanylhydrazone series indicated that substitution of the benzyl group at the para-position was well tolerated. Substitution at the 5-position of the central phenyl ring was critical for potency. Replacement of the guanylhydrazone group led to the discovery of a novel series of CCR5 antagonists.
Syntheses of Biscationic, Trypanocidal 1-Benzofuran Compounds
Dann, Otto,Char, Helmut,Griessmeier, Helmut
, p. 1836 - 1869 (2007/10/02)
2-Phenyl-1-benzofurans with the substituents Br, NO2, CN, and -NH2, -NH-C(=NH)-NH2, -C(=NH)-NH2, in 4',5-position were synthesized. - For arylated formamidine derivatives a simple new preparation was found by reacting amine hydrochlorides with dimethylformamide in the presence of cyanamide. - Based on 5- or 6-cyano-1-benzofuran-2-carboxylates a series of α,ω-bis(1-benzofuran-2-yl) derivatives with cyano-, amidino-, or imidazolinyl groups in 5- or 6-position was prepared.
