841214-40-2Relevant academic research and scientific papers
Redox isomerization via azomethine ylide intermediates: N-alkyl indoles from indolines and aldehydes
Deb, Indubhusan,Das, Deepankar,Seidel, Daniel
supporting information; experimental part, p. 812 - 815 (2011/04/22)
Indolines react with aromatic and heteroaromatic aldehydes to yield N-alkyl indoles in a benzoic acid catalyzed redox isomerization reaction. Azomethine ylides are intermediates in this process which was established by intramolecular [3 + 2] trapping expe
A free radical cyclization approach to indolo-benzodiazocine derivatives
Bremner, John B.,Sengpracha, Waya
, p. 941 - 953 (2007/10/03)
A versatile route to indolo[2,1-d][1,5]benzodiazocine derivatives has been developed based on a free radical cyclization approach from 1-substituted indole derivatives with appropriately positioned haloacetamide functionalities. Fair yields of the indole- and dihydroindole-fused eight-membered ring derivatives were obtained from N-substituted iodo- and bromoacetamide precursors. Synthetic and mechanistic aspects of the regiospecific cyclization are discussed.
