84123-04-6

Basic information

• Product Name: Ethanone, 1-(5-methyl-2-nitro-1H-imidazol-4-yl)- (9CI)
• Synonyms: Ethanone, 1-(5-methyl-2-nitro-1H-imidazol-4-yl)- (9CI)
• CAS NO: 84123-04-6
• Molecular Formula: C6H7N3O3
• Molecular Weight: 169.13808
• Product Categories: ACETYLGROUP
• Mol File: 84123-04-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(5-methyl-2-nitro-1H-imidazol-4-yl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(5-methyl-2-nitro-1H-imidazol-4-yl)- (9CI)(84123-04-6)
• EPA Substance Registry System: Ethanone, 1-(5-methyl-2-nitro-1H-imidazol-4-yl)- (9CI)(84123-04-6)

Safety Data

• Hazardous Substances Data: 84123-04-6(Hazardous Substances Data)

Upstream product

• 40483-45-2 4⁽⁵⁾-acetyl-5⁽⁴⁾-methyl-2-aminoimidazole 

Downstream Products

• 138914-61-1 1-[1-(3-Chloro-2-hydroxy-propyl)-5-methyl-2-nitro-1H-imidazol-4-yl]-ethanone 
• 138914-62-2 3-(4-Acetyl-5-methyl-2-nitro-imidazol-1-yl)-propionitrile 

Relevant articles and documents

Potential Radiosensitizing Agents III: 2-Nitro-4-Acetylimidazole Analogs

New analogs of 2-nitroimidazole have been synthesized in an effort to minimize the toxicity and increase selective sensitization of hypoxic mammalian cells toward lethal effects of ionizing radiation. 2-Nitro-4(5)-acetyl-5(4)-methylimidazole was synthesized from the corresponding 2-amino analog and then reacted with oxiranes to produce the corresponding 1-substituted 2-propanol and 3-methoxy-2-propanol derivatives.The biological results of radiosensitizing activity of these agents against Chinese hamster cells (V-79) indicated that the 3-methoxy-2-propanol derivative was a more effective radiosensitizer than misonidazole in vitro.Evaluation of the acute toxicity of these agents as determined by LD50 demonstrated no significant difference between these agents and misonidazole suggesting that the 3-methoxy-2-propanol analog may posess a therapeutic advantage over misonidazole.