841236-83-7Relevant academic research and scientific papers
N-glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors
Yamamoto, Yasuo,Kawanishi, Eiji,Koga, Yuichi,Sakamaki, Shigeki,Sakamoto, Toshiaki,Ueta, Kiichiro,Matsushita, Yasuaki,Kuriyama, Chiaki,Tsuda-Tsukimoto, Minoru,Nomura, Sumihiro
, p. 5641 - 5645 (2013)
Inhibition of renal sodium-dependent glucose cotransporter 2 (SGLT2) increases urinary glucose excretion (UGE), and thus reduces blood glucose levels in hyperglycemia. A series of N-glucosides was synthesized for biological evaluation as human SGLT2 (hSGLT2) inhibitors. Among these compounds, N-glucoside 9d possessing an indole core structure showed good in vitro activity (IC50 = 7.1 nM against hSGLT2). Furthermore, 9d exhibited favorable in vivo potency with regard to UGE in rats based on good pharmacokinetic profiles.
