84125-07-5Relevant academic research and scientific papers
Organocatalytic Biomimetic Decarboxylative Aldol Reaction of Fluorinated β-Keto Acids with Unprotected Isatins
Li, Yin-Long,Wang, Xue-Lin,Xiao, Dan,Liu, Ming-Ying,Du, Yunfei,Deng, Jun
, p. 4147 - 4152 (2018)
A facile asymmetric synthesis of fluorinated 3-hydroxyoxindoles through the biomimetic decarboxylative aldol reaction of fluorinated β-keto acids with unprotected isatins catalyzed by quinine-derived urea catalyst has been achieved. One of the features of this work is that the easily available α, α-difluoro/α-monofluoro-β-keto acids have been first applied in the enantioselective synthesis of fluorinated compounds as the masked fluoroenolates. Furthermore, the utility of this method was demonstrated by its ability to access a series of difluorinated 3-hydroxyoxindoles with up to 95% ee and monofluorinated 3-hydroxyoxindoles with up to 90 : 10 d.r. and 94% ee. (Figure presented.).
