841250-99-5Relevant academic research and scientific papers
Pyrrolidinohydroquinazolines - A novel class of CCR3 modulators
Anderskewitz, Ralf,Bauer, Rolf,Bodenbach, Gisela,Gester, Dirk,Gramlich, Bernd,Morschhaeuser, Gerd,Birke, Franz W.
, p. 669 - 673 (2005)
A novel class of CCR3 modulators is described. Starting with lead compound 4a (Ki: 110 nM), which turned out to be an antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (Ki: 28 nM), which surprisingly
PYRROLIDINOHYDROCHINAZOLINES
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Page 28, (2010/02/08)
The invention relates to the novel compounds of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar1, Ar2, A, R1, R2, R3, E1, E2, X a
