84131-91-9

Basic information

• Product Name: (S)-(+)-2-METHYLBUTYRIC ANHYDRIDE
• Synonyms: (S)-(+)-2-METHYLBUTYRIC ANHYDRIDE;(S)-2-Methylbutanoic anhydride;(S)-(+)-2-Methylbutyric anhydride 95%
• CAS NO: 84131-91-9
• Molecular Formula: C₁₀H₁₈O₃
• Molecular Weight: 186.25
• Product Categories: Carboxylic Acid Anhydrides;Chiral Building Blocks;Organic Building Blocks
• Mol File: 84131-91-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 60 °C0.2 mm Hg(lit.)
• Flash Point: 194 °F
• Appearance: /
• Density: 0.934 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: n20/D 1.418(lit.)
• CAS DataBase Reference: (S)-(+)-2-METHYLBUTYRIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-METHYLBUTYRIC ANHYDRIDE(84131-91-9)
• EPA Substance Registry System: (S)-(+)-2-METHYLBUTYRIC ANHYDRIDE(84131-91-9)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 84131-91-9(Hazardous Substances Data)

Usage

General Description

(S)-(+)-2-Methylbutyric anhydride is a chemical compound with the molecular formula C9H16O3. It is an anhydride derivative of (S)-(+)-2-methylbutyric acid, and is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and fragrance compounds. It is a highly reactive compound due to its anhydride structure, and is often used as a reagent in organic synthesis reactions. Additionally, it can be used as a chiral building block in the preparation of chiral compounds. Its unique chemical properties and versatility make it an important compound in organic synthesis and drug discovery.

InChI:InChI=1/C10H18O3/c1-5-7(3)9(11)13-10(12)8(4)6-2/h7-8H,5-6H2,1-4H3/t7-,8-/m0/s1

Upstream product

• 1730-91-2 (S)-2-Methylbutyric acid 

Downstream Products

• 117678-57-6 (1S,2S,2'S)-1-(hydroxymethyl)-2-<<(2'-methyl-1-oxobutyl)oxy>methyl>cyclohex-4-ene 
• 117678-58-7 (1S,2S,2'S)-1,2-bis<(2'-methyl-1-oxobutoxy)methyl>cyclohex-4-ene 
• 37878-21-0 (S)-N-<(S)-2-Methyl-1-oxobutyl>phenylalanin 
• 107692-84-2 (4S)-4-Benzyl-<(1S)-1-methylpropyl>oxazol-5(4H)-on 
• 107692-83-1 (S)-2-((S)-2-Methyl-butyrylamino)-3-phenyl-thiopropionic acid S-phenyl ester 
• 1240486-90-1 allyl 2-O-2(S)-methylbutyryl-3-O-p-methoxybenzyl-4-O-tert-butyldimethylsilyl-α-L-rhamnopyranoside 
• 197853-39-7 ethyl 2,4-di-O-[2(S)-methylbutyryl]-3-O-(p-methoxybenzyl)-1-thio-α-L-rhamnopyranoside 
• 101761-32-4 (1S,2S,4aR,6S,8S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-2,6-dimethyl-8-<(S)-(2-methylbutyryl)oxy>-1-(<(R)-(O-methylmandelyl)oxy>methyl)naphthalene 
• 130710-66-6 <1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-yl (R*)-2-methylbutyrate 
• 116996-46-4 <1S-<1α(R^*),3α,7β,8β(4S^*,6R^*),8aβ>>-8-<2-<6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl 2-methylbutanoate 
• 853193-72-3 (S)-2-Methyl-butyric acid (1S,4aR,7S,8S,8aS)-8-[(R)-3-(2-bromo-acetoxy)-5-trityloxy-pentyl]-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester 
• 50657-07-3 trilobolide 
• 116996-39-5 (S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester 
• 138505-84-7 (S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester 

Relevant articles and documents

Total synthesis of the hypocholesterolemic agent compactin

A total synthesis of ( plus )-compactin (ML-236B), a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, is presented. The key chiral hexahydronaphthalene intermediate was efficiently synthesized in 70% overall yield from the optically active diol. In turn, the diol was obtained via microbiological reduction of the racemic dione. ( plus )-Compactin was prepared in 14 steps from the chiral hexahydronaphthalene intermediate in 0. 8% yield. Refs.