84163-76-8

Upstream product

• 84162-97-0 1-acetyl-4-(5-fluoro-2-hydroxybenzoyl)piperidine oxime 
• 108-24-7 acetic anhydride 

Downstream Products

• 84231-29-8 3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-5-fluoro-1,2-benzisoxazole 
• 84163-16-6 4-(5-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride 
• 84163-10-0 3-(1-acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole 

Relevant academic research and scientific papers

Synthesis and Neuroleptic Activity of 3-(1-Substituted-4-piperidinyl)-1,2-benzisoxazoles

The synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles is described.The neuroleptic activity of the series was evaluated by utilizing the climbing mice assay and inhibition of spiroperidol binding.Structure-activity relationships were studied by variation of the substituent on the benzisoxazole ring with concomitant variation of four different 1-piperidinyl substituents.Maximum neuroleptic activity was realized when there was a 6-fluoro substituent on the benzisoxazole ring.The 1-piperidinyl substituent appeared less significant, although in most cases, the (1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl group imparted maximum potency.The most potent compound in both assays was 6-fluoro-3--4-piperidinyl>-1,2-benzisoxazole (11b).

3-(4-Piperidyl)-1,2-benzisoxales

Novel 3-(4-piperidyl)-1,2-benzisoxazoles, intermediates and processes for the preparation thereof, and methods for alleviating pain utilizing compounds or compositions thereof are disclosed.