84165-39-9Relevant academic research and scientific papers
A new fluorescent "turn-on" chemodosimeter for the detection of hydrogen sulfide in water and living cells
El Sayed, Sameh,De La Torre, Cristina,Santos-Figueroa, Luis E.,Perez-Paya, Enrique,Martinez-Manez, Ramon,Sancenon, Felix,Costero, Ana M.,Parra, Margarita,Gil, Salvador
, p. 25690 - 25693 (2013)
A new fluorescent turn-on probe for the selective detection of hydrogen sulfide in water and living cells based on a 8-hydroxyquinoline fluorophore functionalized with a 2,6-dinitrophenyl ether moiety has been developed.
2,4-dinitrophenyl ether-containing chemodosimeters for the selective and sensitive in vitro and in vivo detection of hydrogen sulfide
El Sayed, Sameh,De La Torre, Cristina,Santos-Figueroa, Luis E.,Martinez-Manez, Ramon,Sancenon, Felix,Orzaez, Mar,Costero, Ana M.,Parra, Margarita,Gil, Salvador
, p. 244 - 254 (2015/10/20)
Four probes (i.e. D1-D4) for the selective and sensitive fluorogenic detection of HS- have been prepared and characterised. HEPES (10 mM, pH 7.4)-DMSO 99:1 v/v solutions of D1-D4 are essentially non-fluorescent. Changes in the emission using D1-D4 in the presence of anions (F-, Cl-, Br-, I-,N-3, CN-, SCN-, AcO-,CO2-3 ,PO2-4,SO2-4, HS- and OH-), biothiols (GSH, Cys, Hcy, Me-Cys and lipoic acid), reducing agents (SO2-3 and S2O2-3) and oxidants (H2O2) demonstrated that only HS- is able to induce the appearance of intense emission bands in the 400-520 nm range in the four probes. The selectivity observed was ascribed to a unique hydrogen sulfide-induced hydrolysis of the 2,4-dinitrophenyl ether moiety that yielded the corresponding free highly fluorescent alcohols. The potential detection of intracellular HS- was also studied.
