842-32-0Relevant academic research and scientific papers
Serine protease mechanism-based mimics. Direct evidence for a transition state bridge proton in stable potentials
Bethencourt, Loengrid,Nunez, Oswaldo
, p. 2105 - 2113 (2008)
(Chemical Equation Presented) We have synthesized 1-(2-hydroxyacetyl) piperidine-2-one (2) and 1-(2-hydroxyacetyl)azepan-2-one (3). Equilibrium (Kf) between the free alcohol (open form) and the tetrahedral intermediate (cyclol) is readily estab
Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions
Stephens, Thomas C.,Lawer, Aggie,French, Thomas,Unsworth, William P.
supporting information, p. 13947 - 13953 (2018/09/14)
Macrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3- or 4-atom iterative ring expansion protocol. The products can also be expanded using amino acid-based linear fragments, meaning that macrocycles with precise
