842-73-9

Upstream product

• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 99-81-0 4-Nitrophenacyl bromide 
• 1003-68-5 5-methyl-2-pyridone 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 118000-51-4 N-[4-(6-Methyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-acetamide 
• 887577-09-5 4-{6-methylimidazo[1,2-a]pyridin-2-yl}aniline 

Relevant academic research and scientific papers

Application of Imidazopyridine Derivatives in Regenerative Medicine

A method of producing a pluripotent stem cell is provided. The method is comprising contacting a non-pluripotent donor cell obtained from a mammalian donor with a compound characterized by general formulas (1) and (3). Furthermore, methods for inducing OCT4 and NANOG, increasing histone 3 lysine methylation and the maintenance of pluripotency are provided.

The flocculated acryloyldimethyltauric molecule ligand

Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

A copper-catalyzed multi-component reaction accessing fused imidazo-heterocycles via C-H functionalization

An efficient synthesis of fused imidazo-heterocycles is described using Cu(OTf)2 in [bmim]BF4 by the multi-component reaction of pyridin-2(1H)-one or thiazol/benzo[d]thiazol-2(3H)-ones with O-tosylhydroxyl amine and acetophenones under microwave irradiation. The present method is very rapid and the product formation occurs via a C-H functionalization/tandem addition-cyclization process. The ionic liquid containing copper triflate is recovered and reused four times.

Copper catalyzed tandem oxidative C-H amination/cyclizations: Direct access to imidazo[1,2-a]pyridines

A simple and convenient strategy is described for the synthesis of imidazo[1,2-a]pyridines via inexpensive copper-catalyzed tandem imine formation and intramolecular aerobic oxidative C-H bond amination/cyclizations. An array of imidazo[1,2-a]pyridines were prepared by the reaction of readily available acetophenones and 2-aminopyridines in good to excellent yields (48-92%). The scope of the method was validated by a single step synthesis of Zolimidine, a drug used for peptic ulcers, in 61% yield. The Royal Society of Chemistry 2013.

3-(acylaminomethyl)imidazo[1,2-a]pyridine derivatives and pharmaceutical compositions

A compound which is a 3-(acylaminomethyl)imidazo[1,2-a]pyridine derivative of formula (I) STR1 or a pharmacologically acceptable acid addition salt is useful in therapy.