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Δ6-PGI1, also known as delta-6-PGI1, is a chemical compound that is a precursor in the biosynthesis of prostaglandins, which are lipid compounds derived from fatty acids and play a crucial role in various physiological processes, including inflammation, pain, and blood clotting. It is an intermediate in the arachidonic acid metabolic pathway, which is involved in the production of various prostaglandins and thromboxanes. Δ6-PGI1 is specifically involved in the conversion of arachidonic acid to prostaglandin I2 (PGI2), which is a vasodilator and has antiplatelet effects, making it significant in cardiovascular health. The compound is also of interest in medical research due to its potential therapeutic applications in conditions related to blood flow and inflammation.

84202-77-7

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84202-77-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 84202-77-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,2,0 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 84202-77:
(7*8)+(6*4)+(5*2)+(4*0)+(3*2)+(2*7)+(1*7)=117
117 % 10 = 7
So 84202-77-7 is a valid CAS Registry Number.

84202-77-7Downstream Products

84202-77-7Relevant academic research and scientific papers

Nitro-Olefin Trapping Reactions of Enolates In Situ Generated by Conjugate Addition Reaction: Short Syntheses of PGE1, 6-Oxo-PGE1, 6-Oxo-PGF1α, and PGI2

Tanaka, Toshio,Hazato, Atsuo,Bannai, Kiyoshi,Okamura, Noriaki,Sugiura, Satoshi,et al.

, p. 813 - 824 (2007/10/02)

The nitro-olefin trapping of the enolates in situ generated by conjugate addition of organocopper reagents to the chiral oxygenated cyclopentenone synthon, R-4, gives the three-component coupling products in a regiospecific manner.The intermediary nitronate anion 17 is further transformed into the nitro compound or 6-oxo-PGE1 (19) in a single pot.This coupling reaction is applicable to syntheses of naturally occurring prostaglandins such as PGE1, 6-oxo-PGF1α, and PGI2.

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