84207-77-2

Upstream product

• 84207-76-1 N⁶-benzoyl-2'-deoxy-3',6'-O-(tetraisopropyldisiloxane-1,3-diyl)neplanocin A 
• 84207-75-0 N-[9-((2R,3R,3aR)-3-Iodo-5,5,7,7-tetraisopropyl-2,3,3a,9-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide 

Relevant academic research and scientific papers

Nucleosides and Nucleotides. XXXXV. Facile Deoxygenation of Neplanocin A and Nucleosides by the Use of Tri-n-butyltin Hydride

2'(R)-Halogeno-2'-deoxyneplanocin A's were hydrogenated with tri-n-butyltin hydride to yield 2'-deoxyneplanocin A.The same compound was obtained by reduction ot the 2'-O-(1-imidazolyl)thiocarbonyl derivative of neplanocin A.This procedure was also applicable to the synthesis of 2'-deoxyadenosine and -guanosine from the corresponding ribosides.Treatment of a neplanocin 2',3'-O-cyclic thiocarbonate with tri-n-butyltin hydride gave 3'-deoxyneplanocin selectively in high yield.Keywords --- neplanocin A; nucleoside antibiotic; 2'-deoxyneplanocin A; 3'-deoxyneplanocin A; tri-n-butyltin hydride; radical reduction; 2'-deoxyribonucleosides; NMR; 2'-deoxyadenosine; 2'-deoxyguanosine