84210-26-4

Basic information

• Product Name: NZ-419,5-HYDROXY-1-METHYLIMIDAZOLIDINE-2,4-DIONE
• Synonyms: NZ-419,5-HYDROXY-1-METHYLIMIDAZOLIDINE-2,4-DIONE;5-hydroxy-1-methylhydantoin;5-hydroxy-1-methylimidazolidine-2,4-dione;1-methyl-5-hydroxy-imidazoline-2,4-dione
• CAS NO: 84210-26-4
• Molecular Formula: C₄H₆N₂O₃
• Molecular Weight: 130.1
• Mol File: 84210-26-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.516g/cm³
• Refractive Index: 1.549
• CAS DataBase Reference: NZ-419,5-HYDROXY-1-METHYLIMIDAZOLIDINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: NZ-419,5-HYDROXY-1-METHYLIMIDAZOLIDINE-2,4-DIONE(84210-26-4)
• EPA Substance Registry System: NZ-419,5-HYDROXY-1-METHYLIMIDAZOLIDINE-2,4-DIONE(84210-26-4)

Safety Data

• Hazardous Substances Data: 84210-26-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H6N2O3/c1-6-3(8)2(7)5-4(6)9/h3,8H,1H3,(H,5,7,9)

Upstream product

• 615-77-0 1-methyluracil 
• 122641-44-5 5-acetoxy-1-methylimidazolidine-2,4-dione 
• 598-50-5 N-Methylurea 
• 113259-78-2 5-Bromo-1-methyl-imidazolidine-2,4-dione 
• 298-12-4 Glyoxilic acid 
• 563-96-2 2,2-dihydroxyacetic acid 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Downstream Products

• 680976-39-0 (5R,1'R)-1-methyl-5-(1'-phenylethoxy)hydantoin 
• 680974-14-5 (5S,1'R)-1'-methyl-5-(1'-phenylethoxy)hydantoin 
• 680976-43-6 (5R,1'S)-1-methyl-5-(1'-phenylethoxy)hydantoin 
• 680974-12-3 (5S,1'S)-1-methyl-5-(1'-phenylethoxy) hydantoin 
• 616-04-6 1-methyldiazolidine-2,4-dione 

Relevant articles and documents

NOVEL CRYSTAL FORM OF 5-HYDROXY-1-METHYLHYDANTOIN

Conventional I-form crystals of 5-hydroxy-1-methylhydantoin contain, remaining therein in a considerable amount, the organic solvent used in a purification step. In contrast, in II-form crystals, the amount of the organic solvent remaining therein is smaller than the detection limit. Namely, the II-form crystals contain substantially no residual organic solvent. The novel II-form crystals of 5-hydroxy-1-methylhydantoin obtained through recrystallization from water not only contain substantially no residual organic solvent, but also have a high bulk density and are hence advantageous for pharmaceutical preparation. They further have properties advantageous for production, such as low adhesion. The crystals are significantly useful as a material for medicines required to have high safety, such as drugs for renal insufficiency.

Hydantoin derivatives and pharmaceutical compositions containing them

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Ozonolysis of Uracils in Water

The ozonolysis of uracils unsubstituted at the 1-position gave new 1-acyl-5-hydroxyhydantoins and 5-hydroxyhydantoins in water, while that of 1-substituted uracils gave the corresponding 5-hydroxyhydantoins in low yields.The structure of 1-acetyl-5-hydroxy-5-methylhydantoin was determined by X-ray crystallography.