842103-85-9Relevant academic research and scientific papers
Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes
Liang, Gui-Bai,Qian, Xiaoxia,Feng, Dennis,Biftu, Tesfaye,Eiermann, George,He, Huaibing,Leiting, Barbara,Lyons, Kathy,Petrov, Aleksandr,Sinha-Roy, Ranabir,Zhang, Bei,Wu, Joseph,Zhang, Xiaoping,Thornberry, Nancy A.,Weber, Ann E.
, p. 1903 - 1907 (2008/02/04)
Following the discovery of N-acyl-1,4-diazepan-2-one as a novel pharmacophore for potent and selective DPP-4 inhibitors, optimization of this new lead with different substitution on the seven-membered ring resulted in several highly potent and selective,
