84211-94-9Relevant articles and documents
β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells
Malebari, Azizah M.,Greene, Lisa M.,Nathwani, Seema M.,Fayne, Darren,O'Boyle, Niamh M.,Wang, Shu,Twamley, Brendan,Zisterer, Daniela M.,Meegan, Mary J.
, p. 261 - 285 (2017/03/09)
Glucuronidation by uridine 5-diphosphoglucuronosyl transferase enzymes (UGTs) is a cause of intrinsic drug resistance in cancer cells. Glucuronidation of combretastatin A-4 (CA-4) was previously identified as a mechanism of resistance in hepatocellular ca
Synthesis and serotonin transporter activity of sulphur-substituted α-alkyl phenethylamines as a new class of anticancer agents
Cloonan, Suzanne M.,Keating, John J.,Butler, Stephen G.,Knox, Andrew J.S.,Jorgensen, Anne M.,Peters, Guenther H.,Rai, Dilip,Corrigan, Desmond,Lloyd, David G.,Williams, D. Clive,Meegan, Mary J.
scheme or table, p. 4862 - 4888 (2010/01/16)
The discovery that some serotonin reuptake transporter (SERT) ligands have the potential to act as pro-apoptotic agents in the treatment of cancer adds greatly to their diverse pharmacological application. 4-Methylthioamphetamine (MTA) is a selective ligand for SERT over other monoamine transporters. In this study, a novel library of structurally diverse 4-MTA analogues were synthesised with or without N-alkyl and/or C-α methyl or ethyl groups so that their potential SERT-dependent antiproliferative activity could be assessed. Many of the compounds displayed SERT-binding activity as well as cytotoxic activity. While there was no direct correlation between these two effects, a number of derivatives displayed anti-tumour effects in lymphoma, leukaemia and breast cancer cell lines, showing further potential to be developed as possible chemotherapeutic agents.
Reaction of Styrene 3,4-Oxide with Ethanediol and Dehydration to Ethylthiostyrenes
Watabe, Tadashi,Hiratsuka, Akira,Sone, Tomomichi,Ishihama, Tetsuya
, p. 585 - 586 (2007/10/02)
Styrene 3,4-oxide reacts with the nucleophile ethanediol, and the product is dehydrated to give three isomeric ethylthiostyrenes via the corresponding ethylthiovinylcyclohexadienols without formation of thiiranium ions as intermediates.
