842115-87-1

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-(2-fluorophenyl)thiazole-4-carboxylate is used as a building block for the synthesis of various pharmaceutical compounds due to its unique structure and properties.
Used in Agrochemical Industry:
Ethyl 2-(2-fluorophenyl)thiazole-4-carboxylate is used as a building block for the synthesis of various agrochemical compounds, potentially contributing to the development of new pesticides or herbicides.
Used in Material Science:
Ethyl 2-(2-fluorophenyl)thiazole-4-carboxylate is used as a building block for the synthesis of various materials, potentially contributing to the development of new materials with unique properties.
Used in Biological Research:
Ethyl 2-(2-fluorophenyl)thiazole-4-carboxylate is used as a compound for biological research to explore its potential biological activities and therapeutic uses, although further research is needed to fully understand its potential in these areas.

Upstream product

• 868-59-7 L-cysteine ethyl ester hydrochloride 
• 446-52-6 2-Fluorobenzaldehyde 
• 70-23-5 ethyl Bromopyruvate 
• 75907-82-3 2-fluorobenzothioamide 
• 394-47-8 2-fluorobenzonitrile 

Relevant academic research and scientific papers

I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

The efficient synthesis of 2-substituted thiazoles and benzothiazoles has been accomplished employing readily available cysteine esters and 2-aminobenzenethiols as N and S sources. The reaction proceeds under an I2/TBHP system and involves a on

Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new oxadiazole and thiazole analogs

A series of 2-adamantyl-5-arylthiazolyl-1,3,4-oxadiazoles 7a–x together with thiazoles 13 and 14 were synthesized. Compounds 7a–l, 13, and 14 were tested in vitro with the aim of identifying novel lead compounds active against human immunodeficiency virus type-1 and human immunodeficiency virus type-2 activity in MT-4 cells. Title compounds were also tested against representatives of Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Salmonella spp.), various mycobacterial strains (Mycobacterium fortuitum and Mycobacterium smegmatis), yeast (Candida albicans), and mold (Aspergillus fumigatus). None of the compounds showed antiviral or antimicrobial activity, except compounds 13 and 14 exhibited anti-human immunodeficiency virus-1 activity with EC50 values of 1.79 and 2.39 μM with Selectivity index = 18 and 4, respectively. On the other hand, compounds 7a and 7j showed a marked cytotoxicity against the human CD4+ lymphocytes (MT-4). Therefore, 7a and 7j were evaluated for their antiproliferative activity against two solid tumor-derived cell lines, which exhibited IC50 values of 8.1 ± 0.10 μM and 4.8 ± 0.08 μM against Hep-G2 cell lines, respectively.

Steric and electronic factors influence regio-isomeric thiazole formations between substituted benzothioamides and ethyl bromopyruvate

We observed unexpected thiazole 1B formation when 2,6- dichlorobenzothioamide 1 and ethyl bromopyruvate were reacted under basic conditions at elevated temperatures in ethanol. Thiazole 1B, regio-isomeric to that expected under conventional Hantzsch condi