842136-14-5

Usage

Molecular class

Esters

Derived from

Carboxylic acid, indazole, 4-ethylphenylmethyl

Potential applications

Pharmaceutical development, drug synthesis

Biological activity

Unknown, but may have medicinal properties

Chemical structure

Unique, valuable building block in pharmaceutical synthesis

Upstream product

• 908375-64-4 4-ethylbenzylzinc bromide 
• 290368-00-2 tert-butyl 3-iodo-1H-indazole-1-carboxylate 

Downstream Products

• 842136-16-7 C₁₆H₁₆N₂ 

Relevant academic research and scientific papers

N-glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors

Inhibition of renal sodium-dependent glucose cotransporter 2 (SGLT2) increases urinary glucose excretion (UGE), and thus reduces blood glucose levels in hyperglycemia. A series of N-glucosides was synthesized for biological evaluation as human SGLT2 (hSGLT2) inhibitors. Among these compounds, N-glucoside 9d possessing an indole core structure showed good in vitro activity (IC50 = 7.1 nM against hSGLT2). Furthermore, 9d exhibited favorable in vivo potency with regard to UGE in rats based on good pharmacokinetic profiles.