842155-45-7

Usage

Chemical Category

Ketones

Hydroxy Group

Present

Bromophenyl Group

Attached to propanone backbone

Usage

Organic synthesis, medicinal chemistry (building block for pharmaceuticals and bioactive molecules), synthesis of organic compounds, reagent in chemical reactions

Industries

Pharmaceuticals, chemical research

Properties

Valuable and versatile compound

Upstream product

• 19829-31-3 1-(3-bromophenyl)-1-propanone 
• 842155-44-6 acetic acid 2-(3-bromo-phenyl)-1-methyl-2-oxo-ethyl ester 

Downstream Products

• 842155-42-4 4-(3-bromo-phenyl)-5-methyl-oxazol-2-ylamine 
• 842155-43-5 5-(3-bromo-phenyl)-4-methyl-oxazol-2-ylamine 

Relevant academic research and scientific papers

Green preparation method α - hydroxyketone

The invention relates to a green preparation method of alpha-hydroxyketone. The method comprises the following steps: adding ketone, iodine, 1,4-diazabicyclo[2.2.2]octane and methanol into a glass reaction bottle in sequence; then stirring and reacting for 14 to 30h at room temperature in an air atmosphere under the irradiation of a 23W compact type fluorescent lamp, so as to obtain a reaction mixture; carrying out silica gel column chromatographic separation to obtain the pure alpha-hydroxyketone. The green preparation method provided by the invention has the characteristics of greenness, high efficiency, simplicity in operation, moderate conditions, wide applicability and easiness for industrialization.

Iodine promoted α-hydroxylation of ketones

A novel method for α-hydroxylation of ketones using substoichiometric amount of iodine under metal-free conditions is described. This method has been successfully employed in synthesizing a variety of heterocyclic compounds, which are useful precursors. α-Hydroxylation of diketones and triketones are illustrated. This strategy provides a novel, efficient, mild and inexpensive method for α-hydroxylation of aryl ketones using a sub-stoichiometric amount of molecular iodine.

5-HT2B RECEPTOR ANTAGONISTS

Compounds of formulae: (I), (II), (IIIa), (IIIb), (IVa) and (IVb): or a pharmaceutically acceptable salt thereof, for use as pharmaceuticals, in particular for the treatment of a condition alleviated by antagonism of a 5-HT2B receptor.