84225-91-2

Basic information

• Product Name: Benzoyl chloride, 3-bromo-2,6-dimethoxy-
• CAS NO: 84225-91-2
• Molecular Formula: C9H8BrClO3
• Molecular Weight: 279.518
• Mol File: 84225-91-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 3-bromo-2,6-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 3-bromo-2,6-dimethoxy-(84225-91-2)
• EPA Substance Registry System: Benzoyl chloride, 3-bromo-2,6-dimethoxy-(84225-91-2)

Safety Data

• Hazardous Substances Data: 84225-91-2(Hazardous Substances Data)

Upstream product

• 73219-89-3 3-bromo-2,6-dimethoxybenzoic acid 
• 1466-76-8 2-6-dimethoxybenzoic acid 

Downstream Products

• 84225-77-4 3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,6-dimethoxy-benzamide 
• 102805-72-1 N-[2-(Benzyl-methyl-amino)-ethyl]-3-bromo-2,6-dimethoxy-benzamide; hydrochloride 
• 102805-56-1 N-[2-(Benzyl-propyl-amino)-ethyl]-3-bromo-2,6-dimethoxy-benzamide 
• 125558-35-2 methyl 3-bromo-2,6-dimethoxybenzamidoacetate 
• 82935-51-1 (S)-2-<(3-bromo-2,6-dimethoxybenzamido)methyl>pyrrolidine 
• 102805-64-1 3-bromo-2-hydroxy-6-methoxy-N-<2-(N'-benzyl-N'-methyl)aminoethyl>benzamide 
• 102805-75-4 3-bromo-2-hydroxy-6-methoxy-N-(diethylaminoethyl)benzamide hydrochloride 
• 96947-80-7 3-Bromo-6-hydroxy-2-methoxy-N-((S)-1-propyl-pyrrolidin-2-ylmethyl)-benzamide 
• 96947-79-4 3-Bromo-2-hydroxy-6-methoxy-N-((S)-1-propyl-pyrrolidin-2-ylmethyl)-benzamide 
• 125558-36-3 5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid 
• 125558-33-0 N-ethyl-5-(3-bromo-2,6-dimethoxybenzamido)-4-oxopentanamide 
• 125558-32-9 5-(3-bromo-2,6-dimethoxybenzamido)-4-oxopentanoic acid 
• 125558-30-7 5-<(3-bromo-2,6-dimethoxybenzamido)methyl>-1-ethyl-5-hydroxy-2-pyrrolidone 
• 102805-71-0 3-bromo-2,6-dimethoxy-N-(2-diethylaminoethyl)benzamide hydrochloride 

Relevant articles and documents

Structure-activity relationships of a series of substituted benzamides: Potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents

A series of substituted (4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)benzamide derivatives was prepared and evaluated as potential atypical antipsychotic agents. The target compounds were readily prepared from their benzoyl chloride, benzoic acid, or isatoic anhydride precursors, and they were evaluated in vitro for their ability to bind to dopamine D2, serotonin 5-HT2, and serotonin 5-HT1a receptors. To assess the potential antipsychotic activity of these compounds, we investigated their ability to inhibit the apomorphine-induced climbing response in mice. Selected compounds were evaluated further to determine their side-effect potentials. Structure-activity relationships of both mono- and polysubstituted benzamides are discussed herein. While several analogues had potent in vitro and in vivo activities indicative of potential atypical antipsychotic activity, anthranilamide 77 (1192U90) demonstrated a superior pharmacological profile. As a result of this investigation, 1192U90 (2-amino-N-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)benzamide hydrochloride) was selected for further evaluation and is currently in phase I clinical trials as a potential atypical antipsychotic agent.

Synthesis of 5-substituted 5-hydroxy-2-pyrrolidones, metabolites of the antipsychotic benzamide remoxipride.

This paper describes the synthesis of 5-[(3-bromo-2,6-dimethoxybenzamido)-methyl]-5-hydroxy-2-pyrrolidon e (3) and its 1-ethyl analogue 2, two urinary metabolites of the dopamine D-2 antagonist remoxipride [1, (S)-3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl

Synthesis and neuroleptic activity of substituted benzamides related to metoclopramide

Substituted N-(dialkylaminoalkyl)benzamides related to metoclopramide have been synthesized and examined for antagonism of 3H-spiperone receptor binding (in vitro) and the blockade of apomorphine syndrome (in vivo) in the rat. In the series, fo