84259-93-8

Basic information

• Product Name: 2-hydroxy-6-methyl-1-(2-phenylethyl)pyridin-4(1H)-one
• CAS NO: 84259-93-8
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.2744
• Mol File: 84259-93-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 383.8°C at 760 mmHg
• Flash Point: 185.9°C
• Density: 1.195g/cm³
• Vapor Pressure: 1.42E-06mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 2-hydroxy-6-methyl-1-(2-phenylethyl)pyridin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-6-methyl-1-(2-phenylethyl)pyridin-4(1H)-one(84259-93-8)
• EPA Substance Registry System: 2-hydroxy-6-methyl-1-(2-phenylethyl)pyridin-4(1H)-one(84259-93-8)

Safety Data

• Hazardous Substances Data: 84259-93-8(Hazardous Substances Data)

Upstream product

• 675-10-5 4-hydroxy-6-methyl-2-pyron 
• 64-04-0 phenethylamine 

Downstream Products

• 84259-94-9 methyl-6 phenethylamino-4 N-phenethylpyridone-2 
• 208583-82-8 3-Acetyl-7-methyl-6-phenethyl-6H-pyrano[3,2-c]pyridine-2,5-dione 
• 208583-76-0 4-hydroxy-6-methyl-2-oxo-1-phenethyl-1,2-dihydro-3-pyridinecarbaldehyde 
• 265315-65-9 2-amino-7-methyl-5-oxo-6-phenethyl-4-phenyl-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile 
• 195005-29-9 4-Benzylamino-6-methyl-1-phenethyl-1H-pyridin-2-one 

Relevant articles and documents

Triacetic acid lactone as a common intermediate for the synthesis of 4-hydroxy-2-pyridones and 4-amino-2-pyrones

At ambient temperature, triacetic acid lactone reacts with amines to produce 4-amino-2-pyrones. If the temperature is raised to 100 °C, 4-hydroxy-2-pyridones are generated.

Reactivite de la methyl-6 hydroxy-4 pyrone-2 vis-a-vis des amines primaires : synthese de pyridones-2 N-substituees et d'hexanamides intermediaires

In the well-documented (1-7) reaction of ammonia or primary amines with 2-pyrones leading to pyridones, the aliphatic intermediates have never been isolated, except for the reaction of 1 with aniline (8).In this work, the reaction of 4-hydroxy-6-methyl-2-pyrone 1 with various primary amines is studied.Three 5-amino-3-oxo-4-hexaneamides 3 are isolated for the first time and characterized by NMR, IR and mass spectra.The corresponding 4-hydroxy-6-methyl-2-pyridones 4 are obtained by heating intermediates 3.Direct attack of 1 by primary amines yields the same compounds 4 and finally leads to 4-alkyl (or phenyl) amino-6-methyl-2-pyridones 5.Thus, compounds of the type 5 are obtained from 4-hydroxy-6-methyl-2-pyrone 1 in for steps including three successive nucleophilic sustitutions by primary amines.