84275-47-8Relevant academic research and scientific papers
Pd-Catalyzed Decarboxylative Cycloaddition for the Synthesis of Highly Substituted δ-Lactones and Lactams
Shi, Linlin,He, Yingdong,Gong, Jianxian,Yang, Zhen
, p. 324 - 332 (2021)
An efficient palladium-catalyzed decarboxylative cycloaddition process of vinyl cyclic carbonates and vinyloxazolidinones for the synthesis of highly substituted δ-lactone and δ-lactam derivatives was developed. This protocol exhibits several unique characteristics, including broad substrate scope, good functional group tolerance, and operational convenience, which enables a regioselective access to a variety of lactone and lactam scaffolds in moderate to good yield. The redox-neutral catalytic system promotes formation of substituted scaffolds with in situ generation of a cyclic tetra-substituted double bond functionality.
Microbial Reduction of 1,2-Diketones to Optically Active α-Hydroxyketones
Ohta, Hiromichi,Konishi, Jin,Kato, Yasuo,Tsuchihashi, Gen-ichi
, p. 2421 - 2428 (2007/10/02)
The microorganisms that reduce benzil to optically active benzoin were screened.Xanthomonas oryzae IAM 1657 was selected as the best strain, which resulted in the formation of (R)-(-)-benzoin.This biochemical reduction was applied to other 1,2- and 1,3-diketones to find that only 1,2-diarylethanediones were reduced smoothly to afford the corresponding ketols.
