84312-85-6Relevant academic research and scientific papers
Palladium-catalyzed four-component carbonylative synthesis of 2,3-disubstituted quinazolin-4(3H)-ones: Convenient methaqualone preparation
Peng, Jin-Bao,Geng, Hui-Qing,Wang, Wei,Qi, Xinxin,Ying, Jun,Wu, Xiao-Feng
, p. 10 - 13 (2018/07/03)
A palladium-catalyzed four-component carbonylative cyclization reaction for the synthesis of 2,3-disubstituted quinazolin-4(3H)-ones has been developed. A range of different 2,3-disubstituted quinazolin-4(3H)-one derivatives were prepared in moderate to good yields employing simple and readily accessible 2-iodoanilines, nitro compounds and acid anhydrides as the synthetic precursors. Mo(CO)6 acted both as a solid CO source and a reductant. Notably, methaqualone as a sedative and hypnotic medication can be prepared easily in 68% yield (4b) under our conditions as well.
Synthesis of 2,3-disubstituted-4(3H)-quinazolinones using hy-zeolite as reusable catalyst under microwave irradiation
Montazeri, Naser,Pourshamsian, Khalil,Fomani, Arsalan,Kalantarian, Seyd Jafar
experimental part, p. 2805 - 2807 (2012/08/28)
A new heterogeneous catalytic method to synthesize to various 4(3H)-quinazolinone derevatives, using an inexpensive and eco-friendly attractive solid catalyst, zeolite, under solvent-free and microwave irradiation conditions is described. The catalyst activity results suggest that the methodology adopted offers several advantages such as mild reaction conditions, low loading of catalyst, good yields, short reaction time and operational simplicity.
One-pot synthesis of mono- and disubstituted (3H)-quinazolin-4-ones in dry media under microwave irradiation
Dabiri, Minoo,Salehi, Peyman,Mohammadi, Ali A.,Baghbanzadeh, Mostafa
, p. 279 - 287 (2007/10/03)
AlCl3/ZnCl2 mixture supported on silica gel is an efficient medium for one-pot synthesis of (3H)-quinazolin-4-ones in the absence of solvent under microwave irradiation or classical heating. The reaction of orthoesters with 2-aminobenzamides ends up with the formation of monosubstituted (3H)-quinazolin-4-ones. One-pot synthesis of disubstituted (3H)-quinazolin-4- ones is also achieved by the reaction of isatoic anhydride with primary amines and orthoesters.
Montmorillonite K-10 catalysed solvent-free synthesis of 2,3-disubstituted-4(3H)quinazolinones under microwave irradiation
Dabiri,Salehi,Mohammadi, Ali A.,Baghbanzadeh,Kozehgiry, Gh.
, p. 570 - 572 (2007/10/03)
An efficient and rapid synthesis of 2,3-disubstituted-4(3H)quinazolinones by condensation of 2-aminobenzamide (substituted anthraniamides) with orthoesters in the presence of K-10 clay under solvent free conditions using microwave irradiation or classical heating is described.
Some Reactions of 2-(n-Propyl/β-carboxyethyl)-3,1-benzoxazin-4(H)-ones and 2-(n-Propyl/β-carboxyethyl)-4(3H)-quinazolinones
Essawy, A.,El-Hashash, M. A.,El-Gendy, A. M.,Hamad, M. M. M.
, p. 593 - 595 (2007/10/02)
Reaction of 2-(n-propyl/β-carboxyethyl)-3,1-benzoxazin-4-ones (1a,b) with aromatic amines gives 3-aryl-2-(n-propyl/β-carboxyethyl)-4(3H)-quinazolinones (2a-e).Compound 1a reacts with hydrazine hydrate and phenylhydrazine to give 3-amino-2-n-propyl-4(3H)-q
