84314-36-3

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 118-93-4 o-hydroxyacetophenone 
• 82340-49-6 3-(4-hydroxyphenyl)-5-(2-hydroxyphenyl)-isoxazole 
• 99-96-7 4-hydroxy-benzoic acid 
• 2345-34-8 4-acetyloxy-benzoic acid 
• 141993-06-8 3-(4-hydroxyphenyl)-5-tributylstannylisoxazole 
• 533-58-4 2-Iodophenol 

Downstream Products

• 84314-41-0 2-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-1-(4-hydroxy-phenyl)-3-(2-hydroxy-phenyl)-propane-1,3-dione 
• 84314-42-1 1-(4-Hydroxy-phenyl)-3-(2-hydroxy-phenyl)-2-[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-propane-1,3-dione 
• 84314-49-8 3-(4-Hydroxy-benzoyl)-2-(4-nitro-phenyl)-chromen-4-one 
• 84314-51-2 3-(4-Hydroxy-benzoyl)-2-(2-hydroxy-phenyl)-chromen-4-one 
• 84314-48-7 3-(4-Hydroxy-benzoyl)-2-(4-methoxy-phenyl)-chromen-4-one 
• 84314-50-1 2-(4-Chloro-phenyl)-3-(4-hydroxy-benzoyl)-chromen-4-one 
• 4143-63-9 4'-hydroxyflavone 
• 84314-39-6 1-(4-Hydroxy-phenyl)-3-(2-hydroxy-phenyl)-2-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-propane-1,3-dione 
• 84314-40-9 1-(4-Hydroxy-phenyl)-3-(2-hydroxy-phenyl)-2-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-propane-1,3-dione 

Relevant academic research and scientific papers

STILBENES AND CHALCONES FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES

The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

Synthesis of Flavones via Application of the Nitrile Oxide and the Stille Reactions

Hydroxylated and methoxylated benzaldehyde oximes have been chlorinated, dehydrohalogenated and cycloadded to tributylstannylacetylene to give 3-aryl-5-tributylstannylisoxazoles in good to excellent yields.The palladium-catalyzed coupling reaction, the so-called Stille reaction, of hindered and electron-rich 2-iodophenols and a 2-iodo-1,4-benzoquinone with 3-aryl-5-tributylstannyl-isoxazoles gave 3-aryl-5-(2-hydroxyaryl)isoxazoles in moderate to excellent yields.The coupling reaction was studied under various conditions and with various Pd(II) and Pd(0) complexes.Reduction of the 3,5-diarylisoxazoles with H2/Raney-Ni, hydrolysis and acid-catalyzed cyclisation gave flavones.The synthesis of 2-iodo-3,5-dimethoxy-1,4-benzoquinone is described.