84348-40-3Relevant academic research and scientific papers
Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates
Vlahov, Iontcho R.,Qi, Longwu,Kleindl, Paul J.,Santhapuram, Hari K.,Felten, Albert,Parham, Garth L.,Wang, Kevin,You, Fei,Vaughn, Jeremy F.,Hahn, Spencer J.,Klein, Hanna F.,Vetzel, Marilynn,Reddy, Joseph A.,Nelson, Melissa,Nicoson, Jeff,Leamon, Christopher P.
, p. 2921 - 2931 (2017/12/26)
Pyrrolobenzodiazepines (PBDs) and their dimers (bis-PBDs) have emerged as some of the most potent chemotherapeutic compounds, and are currently under development as novel payloads in antibody-drug conjugates (ADCs). However, when used as stand-alone thera
Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors
Shi, Wei,Ma, Haikun,Duan, Yuejiao,Aubart, Kelly,Fang, Yuhong,Zonis, Rimma,Yang, Liping,Hu, Wenhao
scheme or table, p. 1060 - 1063 (2011/03/21)
The synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated to discover SAR at P1′ and P 3′ positions, and most of
