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Usage

Uses

Used in Pharmaceutical Industry:
5-methyl-3H-[1,3,4]thiadiazol-2-one is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential biological activity. It is particularly utilized in the development of drugs targeting neoplasm inhibition, which is the prevention or suppression of the growth of tumors.
Used in Research and Development:
In the field of research and development, 5-methyl-3H-[1,3,4]thiadiazol-2-one serves as a valuable compound for studying the biological activity of neoplasm inhibition. Its unique structure and properties make it an interesting subject for scientific investigations, potentially leading to the discovery of new therapeutic agents and treatment strategies for cancer and other diseases.

Upstream product

• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 1925-76-4 2-Methoxy-5-methyl-1,3,4-thiadiazol 
• 108-33-8 5-methyl-1,3,4-thiadiazol-2-amine 

Downstream Products

• 73956-11-3 3-benzyl-5-methyl-1,3,4-thiadiazol-2(3H)-one 

Relevant academic research and scientific papers

Azo dyes containing 1,3,4-thiadiazole fragment: Synthesis and properties

New 1,3,4-thiadiazole derivatives containing a diazenyl group, as well as both a diazenyl and an imino group, were synthesized and their optical and thermal properties were investigated. Initially, new azo compounds containing an azo group directly in the thiadiazole block were obtained by the coupling of diazonium bisulfates based on the previously known 5-derivatives of 2-amino-1,3,4-thiadiazoles with N,N-dialkyl anilines (N(n-Bu)2, NEt2, and NEt(EtOH)). Schiff bases were obtained by the interaction of p-toluidine, p-phenylenediamine and p-aminophenol with azo compounds containing an aldehyde group in the 1,3,4-thiadiazole ring. The new dyes were characterized by spectral (IR, UV, 1H NMR, 13C NMR and mass spectra) and X-ray analyses. This journal is

Novel Type Elimination Reactions of Sulfoxides Bearing Several Heteroaromatics: Trapping of Sulfines with 2,3-Dimethyl-1,3-butadiene

Previously we reported the novel thioaldehydes generation via thermolyses of phenacyl sulfoxides bearing some heteroaromatics. Thermolysis of sulfoxides (1a,b and 2a-4a) bearing other heterocycles such as thiadiazole, triazole, and tetrazole in the presence of 2,3-dimethyl-1,3-butadiene in dioxane at 100 °C led to the unexpected products 6-substituted-5,6-dihydro-3,4-dimethyl-2H-thiapyran 1-oxide (5a,b). These products were considered to be formed by the Diels-Alder reaction of the diene with the sulfines formed initially by the thermal decomposition of the sulfoxides. The rate acceleration and the improvement of the yield by addition of 1.5 equiv of triethylamine, especially in the case of ethoxycabonylmethyl sulfoxide 1c, was observed. The cis-trans selectivity for sulfine cycloadducts was also studied by NMR spectrometry. The reactions of α-substituted phenacyl sulfoxides 1d-f bearing a phenyl-substituted tetrazolyl group in the presence of the same diene were also studied.