843615-24-7

Upstream product

• 651729-65-6 3-(2-amino-4-methoxy-phenylsulfamoyl)-4-methoxy-benzoic acid 2-(toluene-4-sulfonyl)ethyl ester 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 651729-67-8 4-methoxy-3-[5-methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)-benzimidazole-1-sulfonyl]-benzoic acid 2-(toluene-4-sulfonyl)ethyl ester 

Relevant academic research and scientific papers

Process for preparing isomerically pure prodrugs of proton pump inhibitors

Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.

PRODRUGS OF PROTON PUMP INHIBITORS

Prodrugs of proton pump inhibitors of Formulas 1 through 4, (I-IV), where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.