843651-82-1Relevant articles and documents
Design, synthesis, and biological evaluation of semicarbazide-sensitive amine oxidase (SSAO) inhibitors with anti-inflammatory activity
Wang, Eric Y.,Gao, Hongfeng,Salter-Cid, Luisa,Zhang, Jun,Huang, Li,Podar, Erika M.,Miller, Andrew,Zhao, Jingjing,O'Rourke, Anne,Linnik, Matthew D.
, p. 2166 - 2173 (2006)
In an attempt to examine the effect of inhibition of semicarbazide- sensitive amine oxidase (SSAO; EC 1.4.3.6, also known as VAP-1) as a novel anti-inflammatory target, the structure/mechanism based design and synthesis of a series of novel hydrazino-cont
INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT OF DISEASES
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Page/Page column 59-61, (2010/02/10)
Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylhydrazine compounds, hydroxylamine (aminooxy) compounds, and other compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis.