843653-06-5

Basic information

• Product Name: 1-(4-bromobutyl)-5-fluoro-1H-indole
• Synonyms: 1-(4-bromobutyl)-5-fluoro-1H-indole
• CAS NO: 843653-06-5
• Molecular Formula: C12H13BrFN
• Molecular Weight: 270
• Mol File: 843653-06-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-bromobutyl)-5-fluoro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromobutyl)-5-fluoro-1H-indole(843653-06-5)
• EPA Substance Registry System: 1-(4-bromobutyl)-5-fluoro-1H-indole(843653-06-5)

Safety Data

• Hazardous Substances Data: 843653-06-5(Hazardous Substances Data)

Usage

General Description

1-(4-bromobutyl)-5-fluoro-1H-indole is a chemical compound with the molecular formula C14H16BrFN. It is a synthetic organic compound that consists of a butyl chain attached to a bromine atom and a fluorine atom, with an indole ring structure. 1-(4-bromobutyl)-5-fluoro-1H-indole is commonly used in pharmaceutical and research applications, particularly in the development of new drugs and medications. Its properties and structure make it well-suited for various chemical and biological studies, as well as potential applications in the field of medicine. Additionally, it may have potential uses in the synthesis of other organic compounds for various industrial and research purposes.

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 399-52-0 5-fluoro-1H-indole 

Relevant articles and documents

Design, radiosynthesis and preliminary biological evaluation in mice of a brain-penetrant18f-labelled σ2 receptor ligand

The σ2 receptor (transmembrane protein 97), which is involved in cholesterol homeostasis, is of high relevance for neoplastic processes. The upregulated expression of σ2 receptors in cancer cells and tissue in combination with the antiproliferative potency of σ2 receptor ligands motivates the research in the field of σ2 receptors for the diagnosis and therapy of different types of cancer. Starting from the well described 2-(4-(1H-indol-1-yl)butyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline class of compounds, we synthesized a novel series of fluorinated derivatives bearing the F-atom at the aromatic indole/azaindole subunit. RM273 (2-[4-(6-fluoro-1H-pyrrolo[2,3-b]pyridin-1-yl)butyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline) was selected for labelling with18F and evaluation regarding detection of σ2 receptors in the brain by positron emission tomography. Initial metabolism and biodistribution studies of [18F]RM273 in healthy mice revealed promising penetration of the radioligand into the brain. Preliminary in vitro autoradiography on brain cryosections of an orthotopic rat glioblastoma model proved the potential of the radioligand to detect the upregulation of σ2 receptors in glioblastoma cells compared to healthy brain tissue. The results indicate that the herein developed σ2 receptor ligand [18F]RM273 has potential to assess by non-invasive molecular imaging the correlation between the availability of σ2 receptors and properties of brain tumors such as tumor proliferation or resistance towards particular therapies.

Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2

Novel compounds combining a 5-HT1A moiety (3-aminochroman scaffold) and a 5-HT transporter (indole analogues) linked through a common basic nitrogen via an alkyl chain attached at the 1- or 3-position of the indole were evaluated for dual affin