84366-81-4 Usage
Description
Flavin Adenine Dinucleotide Disodium Salt hydrate is an adenine-containing enzymatic redox cofactor. Also known as flavin cofactors and is critical electron transporter in living systems. FAD has been used as a predominant fluorophore to study unstained eosinophils, which exhibit autofluorescence compared to other leucocytes.
Uses
Used as a redox cofactor (electron carrier) for flavoproteins including succinate dehydrogenase (complex), alpha-ketoglutarate dehydrogenase, apoptosis-inducing factor 2 (AIF-M2) , AMID), folate/FAD-dependent tRNA methyltransferase, and N-hydroxylated flavoprotein monooxygenase.
Biological Activity
Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, a prosthetic group of proteins, involved in several important enzymatic reactions during metabolism.
in vitro
Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.
in vivo
With Flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.
Check Digit Verification of cas no
The CAS Registry Mumber 84366-81-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,3,6 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 84366-81:
(7*8)+(6*4)+(5*3)+(4*6)+(3*6)+(2*8)+(1*1)=154
154 % 10 = 4
So 84366-81-4 is a valid CAS Registry Number.
InChI:InChI=1/C27H33N9O15P2.2Na/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36;;/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43);;/q;2*+1/p-2/t14?,15?,16-,19?,20-,21-,26-;;/m1../s1