84367-96-4

Basic information

• Product Name: N-{[(2R)-1-ethyl-5-oxopyrrolidin-2-yl]methyl}-2-methoxy-5-sulfamoylbenzamide
• CAS NO: 84367-96-4
• Molecular Formula: C₁₅H₂₁N₃O₅S
• Molecular Weight: 355.4093
• Mol File: 84367-96-4.mol
• Article Data: 2

Chemical Properties

• Density: 1.303g/cm³
• Refractive Index: 1.561
• CAS DataBase Reference: N-{[(2R)-1-ethyl-5-oxopyrrolidin-2-yl]methyl}-2-methoxy-5-sulfamoylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{[(2R)-1-ethyl-5-oxopyrrolidin-2-yl]methyl}-2-methoxy-5-sulfamoylbenzamide(84367-96-4)
• EPA Substance Registry System: N-{[(2R)-1-ethyl-5-oxopyrrolidin-2-yl]methyl}-2-methoxy-5-sulfamoylbenzamide(84367-96-4)

Safety Data

• Hazardous Substances Data: 84367-96-4(Hazardous Substances Data)

Upstream product

• 84285-34-7 butyl-5-oxopyroglutamate 
• 84285-35-8 butyl-N-ethyl-5-oxopyroglutamate 
• 84285-36-9 N-ethyl-5-hydroxymethyl-2-pyrrolidinone 
• 21675-62-7 l(-)-glutamic acid 
• 22117-85-7 2-methoxy-5-sulfamoylbenzoic acid 
• 52542-44-6 2-methoxy-5-sulphamoyl-benzoyl chloride 
• 84367-95-3 N-ethyl-α-aminomethyl-2-pyrrolidinone 

Relevant articles and documents

Isolation, identification, and synthesis of the major sulpiride metabolite in primates

The major metabolite of sulpiride, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-sulfamoyl-2-anisamide (I), in the monkey is N-[(1-ethyl-5-oxo-pyrrolidinyl)methyl]-5-sulfamoyl-2-anisamide (II). It is also a metabolite in other laboratory animal species and possibly at very low levels in humans. Treatment of the urine from a monkey dosed orally with 14C-I by dry column chromatography and high-pressure liquid chromatography (HPLC) produced the major metabolite in pure form. Characterization of the purified 14C-radiolabeled metabolite by proton NMR, TLC, HPLC, and chemical ionization mass spectroscopy, along with subsequent comparison of a synthetically prepared sample, gave unequivocal structural confirmation.