843673-36-9

Upstream product

• 994-30-9 triethylsilyl chloride 
• 843673-35-8 (S)-3-tert-Butoxycarbonylamino-3-{3-chloro-4-[(R)-1-((1S,4S)-2-iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-3-trimethylsilanyl-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid methyl ester 
• 843673-43-8 (S)-3-tert-Butoxycarbonylamino-3-{3-chloro-4-[(R)-1-((1S,4S)-2-iodo-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid methyl ester 
• 843673-22-3 (S)-3-tert-Butoxycarbonylamino-3-{3-chloro-4-[(R)-1-((1S,4S)-1-hydroxy-2-iodo-4-methoxymethoxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid methyl ester 
• 791072-89-4 (2S,3S,6S)-2-Ethynyl-4-iodo-6-methoxymethoxy-1-oxa-spiro[2.4]hept-4-ene 

Downstream Products

• 843673-37-0 3-tert-butoxycarbonylamino-3-{3-chloro-4-[1-(2-{2-[2-hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-1,4-dioxa-spiro[4.4]non-2-ylethynyl}-4-methoxymethoxy-1-triethylsilanyloxy-cyclopent-2-enyl)-prop-2-ynyloxy]-5-methoxymethoxy-phenyl}-propionic acid 

Relevant academic research and scientific papers

Synthesis of the C-1027 chromophore framework through atropselective macrolactonization

Long-range steric interactions of the protecting groups of the 1,5-diol were harnessed for the successful atropselective macrolactonization (A) in the synthesis of the C-1027 chromophore framework (see scheme). Subsequent LiN(SiMe3)2