84380-02-9Relevant articles and documents
Glycosides and?amino acyl esters of?carbohydrates as?potent inhibitors of?angiotensin converting enzyme
Lohith,Vijayakumar,Somashekar,Sivakumar,Divakar
, p. 1059 - 1072 (2007/10/03)
About 12 glycosides prepared through amyloglucosidase catalysis and 23 amino acyl esters of carbohydrates prepared through lipase catalysis in organic solvents showed angiotensin converting enzyme (ACE) inhibition activity. Both amino acyl esters of carbohydrates and glycosides exhibited IC50 values for ACE inhibition in the 0.5?mM to 15.7?mM range. Eugenyl-d-glucoside (IC50: 0.5 ± 0.04?mM), l-isoleucyl-d-glucose (IC50: 0.7 ± 0.067?mM), vanillyl-d-sorbitol (IC50: 0.8 ± 0.09?mM), l-histidyl-d-fructose (IC50: 0.9 ± 0.087?mM), l-tryptophanyl-d-fructose (IC50: 0.9 ± 0.092?mM), octyl-d-glucoside (IC50: 1.0 ± 0.093?mM), vanillyl-d-mannoside (IC50: 1.0 ± 0.089?mM), l-valyl-d-mannitol (IC50: 1.0 ± 0.092?mM) and l-phenylalanyl-d-glucose (IC50: 1.0 ± 0.089?mM) were the compounds, which showed the best ACE inhibitory activities.