Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6-[(4-mercaptophenyl)amino]-8a-methoxy-5-methyl-,[1aS-(1aa,8b,8aa,8ba)]- (9CI) is a complex organic compound with a unique chemical structure. It is characterized by its hexahydro-8a-methoxy-5-methyl-6-[(4-mercaptophenyl)amino]-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione backbone. Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6-[(4-mercaptophenyl)amino]-8a-methoxy-5-methyl-,[1aS-(1aa,8b,8aa,8ba)]- (9CI) is a derivative of pyrroloindole, a heterocyclic compound with potential applications in medicinal chemistry and drug development. Its specific stereochemistry is indicated by the [1aS-(1aa,8b,8aa,8ba)] notation, which describes the arrangement of atoms in the molecule. The presence of functional groups such as amino, carbonyl, and mercaptophenyl groups suggests that Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6-[(4-mercaptophenyl)amino]-8a-methoxy-5-methyl-,[1aS-(1aa,8b,8aa,8ba)]- (9CI) may have interesting chemical reactivity and biological activity, making it a subject of interest for further research and development in the field of chemistry and pharmacology.
The CAS Registry Mumber 84397-37-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,3,9 and 7 respectively; the second part has 2 digits, 3 and 7 respectively. Calculate Digit Verification of CAS Registry Number 84397-37: (7*8)+(6*4)+(5*3)+(4*9)+(3*7)+(2*3)+(1*7)=165 165 % 10 = 5 So 84397-37-5 is a valid CAS Registry Number.
84397-37-5SDS
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According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition
Version: 1.0
Creation Date: Aug 18, 2017
Revision Date: Aug 18, 2017
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NSC332374
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84397-37-5Relevant academic research and scientific papers
Mitomycin C Analogues with Aryl Substituents on the 7-Amino Group
Sami, Salah M.,Iyengar, Bhashyam S.,Tarnow, Shirley E.,Remers, William A.,Bradner, William T.,Schurig, John E.
, p. 701 - 708 (2007/10/02)
A series of 30 different N7-phenyl-substituted mitomycin C analogues, including 25 new compounds, was prepared from mitomycin A.Seven of these compounds were clearly superior to mitomycin C in activity against P-388 murine leukemia.The para- and the meta-substituted derivatives were subjected to Hansch analysis, which revealed that the lipid-water distribution coefficient ? was the only significant factor in determining antitumor potency (MED).The substituent electronegativity factor ? was statistically insignificant in determining potency, despite the good correlation of ?P with the polarographic quinone-reduction potential.These results suggest that diffusion into the tumor cell or access to the receptor is more important than bioreductive activation in determining antitumor potency for this particular group of mitosanes.Fifteen new mitomycin C analogues with heterocycles on the 7-amino group also were prepared.Two of them, containing pyrazolyl and aminopyridyl substituents, were more active than mitomycin C against P-388 murine leukemia.No broad correlations could be made among the antitumor potencies and physicochemical properties for this type of analogue.
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