84412-91-9 Usage
Uses
Used in Research and Development:
(-)-12,13-Epoxytrichotheca-9-ene-4β,15-diol 15-[(E)-5-hydroxy-3-methyl-2-pentenoate] is utilized as a subject of study in research and development for understanding its toxicological properties and exploring potential countermeasures or treatments for its adverse effects. This knowledge can contribute to the development of strategies to mitigate the risks associated with exposure to this mycotoxin.
Used in Environmental and Food Safety Monitoring:
In the field of environmental and food safety, (-)-12,13-Epoxytrichotheca-9-ene-4β,15-diol 15-[(E)-5-hydroxy-3-methyl-2-pentenoate] is used as a target for monitoring and detection in order to ensure the safety of food products and prevent contamination. Analytical methods and detection techniques are employed to identify and quantify the presence of this mycotoxin in various samples, allowing for appropriate measures to be taken to protect public health.
Used in Pharmaceutical Development:
Although (-)-12,13-Epoxytrichotheca-9-ene-4β,15-diol 15-[(E)-5-hydroxy-3-methyl-2-pentenoate] is toxic, its unique properties may be leveraged in the pharmaceutical industry for the development of drugs with targeted applications. For instance, understanding its mechanism of action could lead to the design of compounds that exploit similar pathways for therapeutic purposes, while minimizing the toxic effects associated with the parent compound.
Used in Agricultural Practices:
In agriculture, (-)-12,13-Epoxytrichotheca-9-ene-4β,15-diol 15-[(E)-5-hydroxy-3-methyl-2-pentenoate] is a concern due to its presence in fungi and mold that can affect crops. It is used as a reference point for developing strategies to prevent or mitigate the growth of such fungi and mold in agricultural settings, thereby reducing the risk of contamination and ensuring the safety and quality of produce.
Check Digit Verification of cas no
The CAS Registry Mumber 84412-91-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,4,1 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 84412-91:
(7*8)+(6*4)+(5*4)+(4*1)+(3*2)+(2*9)+(1*1)=129
129 % 10 = 9
So 84412-91-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H30O6/c1-13-4-6-20(11-25-18(24)9-14(2)5-7-22)16(8-13)27-17-10-15(23)19(20,3)21(17)12-26-21/h8-9,15-17,22-23H,4-7,10-12H2,1-3H3/b14-9+/t15-,16-,17-,19-,20-,21+/m1/s1
84412-91-9Relevant academic research and scientific papers
Synthesis of Epoxytrichothecenes: Verrucarin J and Verrucarin J Isomers
Roush, William R.,Blizzard, Timothy A.
, p. 1772 - 1783 (2007/10/02)
A five-step synthesis of verrucarin J (1) from verrucarol (2) is described.Esterification of (E)-21 and 2 with DDC in the presence of catalytic DMAP was highly regioselective but afforded a 3-4:1 mixture of (E)-23 and the corresponding Z olefin isomer.Two routes from (E)-23 to seco acid 13 are described, the most efficient of which involves the coupling of (E)-24 ("verrol") with muconate ester 28.Macrolactonization of seco acid 13 via mixed anhydride 31 afforded 55-60percent of 1 together with 25-30percent of E,E,E isomer 32.Although attempts to suppress the formation of 32were unsuccessful, treatment of 32 with I2 in C6H6 effected clean isomerization to a 2:1 mixture of 1 and E,Z,E isomer 33.The overall yield of verrucarin J from verrucarol, after a recycle of 32, was 27-30percent .Also described are syntheses of (Z,E,Z)-verrucarin (40) and Z,E,E isomer 41.Verrucarins 1 and 40 are nearly equipotent in the in vitro L1210 mouse leukemia assay, but the (E,E)-muconate isomers 32 and 41 are less active by an order of magnitude.These data may reflect the solvolytic reactivity of 32 and 41, since these compounds rapidly transesterify in EtOH.Seco acid 13 was essentially inactive in the L1210 assay.
Synthesis of Verrucarin J
Roush, William R.,Blizzard, Timothy A.
, p. 758 - 759 (2007/10/02)
A synthesis of verrucarin J from verrucarol, 3-butyn-1-ol, and malealdehydic acid is described.
