84424-09-9

Usage

InChI:InChI=1/C15H15FN4O3/c1-2-19-7-10(15(22)23)12(21)9-5-11(16)14(18-13(9)19)20-4-3-8(17)6-20/h2,5,7-8H,1,3-4,6,17H2,(H,22,23)

Upstream product

• 84424-08-8 6-Fluoro-4-oxo-7-[3-(2,2,2-trifluoro-acetylamino)-pyrrolidin-1-yl]-1-vinyl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 87939-15-9 ethyl 7-(4-acetyl-1-piperazinyl)-1-(2-chloroethyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 84424-07-7 ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylate 
• 84424-27-1 6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Pyridonecarboxylic acids as antibacterial agents. 4. Synthesis and antibacterial activity of 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo*-1,8- naphthyridine-3-carboxylic acid and its analogues

The title compounds with an amino- and/or hydroxy-substituted cyclic amino group at C-7 were prepared with 1-substituted 7-chloro-, 7-(ethylsulfonyl)-, and 7-(tosyloxy)-6-fluoro-1,4-dihydro-4-oxo-1,8-napthyridine-3-carboxylic acids and their ethyl esters with cyclic amines such as 3-aminopyrrolidine. The N-1 substituent includes ethyl, vinyl, and 2-fluoroethyl groups. As a result of in vitro and in vivo antibacterial screenings, three compounds, 1-ethyl- and 1-vinyl-7-(3-amino-1-pyrrolidine)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyri dine-3-carboxylic acids and 1-vinyl-7-[3-(methylamino)-1-pyrrolidinyl] analogue, were found to be more active than enoxacin and to be worthy of further biological study. Structure-activity relationships are discussed.