84424-25-9Relevant academic research and scientific papers
Pyridonecarboxylic acids as antibacterial agents. 4. Synthesis and antibacterial activity of 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo*-1,8- naphthyridine-3-carboxylic acid and its analogues
Egawa,Miyamoto,Minamida,Nishimura,Okada,Uno,Matsumoto
, p. 1543 - 1548 (2007/10/02)
The title compounds with an amino- and/or hydroxy-substituted cyclic amino group at C-7 were prepared with 1-substituted 7-chloro-, 7-(ethylsulfonyl)-, and 7-(tosyloxy)-6-fluoro-1,4-dihydro-4-oxo-1,8-napthyridine-3-carboxylic acids and their ethyl esters with cyclic amines such as 3-aminopyrrolidine. The N-1 substituent includes ethyl, vinyl, and 2-fluoroethyl groups. As a result of in vitro and in vivo antibacterial screenings, three compounds, 1-ethyl- and 1-vinyl-7-(3-amino-1-pyrrolidine)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyri dine-3-carboxylic acids and 1-vinyl-7-[3-(methylamino)-1-pyrrolidinyl] analogue, were found to be more active than enoxacin and to be worthy of further biological study. Structure-activity relationships are discussed.
Naphthyridine derivatives and their use as anti-bacterials
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, (2008/06/13)
A 1,8-naphthyridine compound of the formula STR1 wherein R is a vinyl or 2-fluoroethyl group, and R1 and R2 are the same or different and each represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms, and the esters thereof and salts thereof. For example, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylic acid and nontoxic salts thereof, which are covered by the aforesaid compound, are useful as an antibacterial agent.
