844443-81-8

Basic information

• Product Name: 4-[(4-amino-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-[(4-amino-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 844443-81-8
• Molecular Formula: C₁₄H₂₃N₅O₃
• Molecular Weight: 309.36412
• Mol File: 844443-81-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(4-amino-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-amino-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester(844443-81-8)
• EPA Substance Registry System: 4-[(4-amino-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester(844443-81-8)

Safety Data

• Hazardous Substances Data: 844443-81-8(Hazardous Substances Data)

Upstream product

• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 844443-80-7 4-[(4-nitro-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 844442-24-6 C₂₁H₂₄F₃N₅O₄ 
• 844442-07-5 C₂₂H₂₈FN₅O₅ 
• 1048675-61-1 C₂₁H₂₅ClFN₅O₄ 
• 902152-88-9 4-([4-(2-chloro-6-methoxy-benzoylamino)-1H-pyrazole-3-carbonyl]-amino)-piperidine-1-carboxylic acid tert-butyl ester 
• 844443-90-9 tert-butyl 4-(4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxamido)piperidine-1-carboxylate 

Relevant articles and documents

Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors

Cyclin-dependent kinases play significant roles in cell cycle progression and are promising targets for cancer therapy. However, most potent CDK inhibitors lack the balance between efficacy and safety because of poor selectivity. Given the roles of CDK2 i

Design and synthesis of 4-(Heterocyclic substituted amino)-1h-pyrazole-3-carboxamide derivatives and their potent activity against acute myeloid leukemia (AML)

Fms-like receptor tyrosine kinase 3 (FLT3) has been emerging as an attractive target for the treatment of acute myeloid leukemia (AML). By modifying the structure of FN-1501, a potent FLT3 inhibitor, 24 novel 1H-pyrazole-3-carboxamide derivatives were designed and synthesized. Compound 8t showed strong activity against FLT3 (IC50: 0.089 nM) and CDK2/4 (IC50: 0.719/0.770 nM), which is more efficient than FN-1501(FLT3, IC50: 2.33 nM; CDK2/4, IC50: 1.02/0.39 nM). Compound 8t also showed excellent inhibitory activity against a variety of FLT3 mutants (IC50 50: 1.22 nM). In addition, compound 8t significantly inhibited the proliferation of most human cell lines of NCI60 (GI50 1 μM for most cell lines). Taken together, these results demonstrated the potential of 8t as a novel compound for further development into a kinase inhibitor applied in cancer therapeutics.

PHARMACEUTICAL COMPOUNDS

The invention provides a combination of a cytotoxic compound or signalling inhibitor and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4- or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C=O, NRg(C=O) or 0(C=O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).